Journal article
Neuroprotection after a first episode of mania: A randomized controlled maintenance trial comparing the effects of lithium and quetiapine on grey and white matter volume
M Berk, O Dandash, R Daglas, SM Cotton, K Allott, A Fornito, C Suo, P Klauser, B Liberg, L Henry, C Macneil, M Hasty, P McGorry, CS Pantelis, M Yöcel
Translational Psychiatry | SPRINGERNATURE | Published : 2017
DOI: 10.1038/tp.2016.281
Abstract
Lithium and quetiapine are effective treatments for bipolar disorder, but their potential neuroprotective effects in humans remain unclear. A single blinded equivalence randomized controlled maintenance trial was conducted in a prospective cohort of firstepisode mania (FEM) patients (n = 26) to longitudinally compare the putative protective effects of lithium and quetapine on grey and white matter volume. A healthy control sample was also collected (n = 20). Using structural MRI scans, voxel-wise grey and white matter volumes at baseline and changes over time in response to treatment were investigated. Patients were assessed at three time points (baseline, 3 and 12-month follow-up), whereas ..
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Grants
Awarded by Stockholms Läns Landsting
Funding Acknowledgements
This study was supported by an unrestricted grant from Astra Zeneca. MB was supported by a National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship 1059660. CS was supported by a NHMRC Career Development Fellowship 1061998. CsP was supported by a NHMRC Senior Principal Research Fellowship (ID: 628386). AF was supported by the Australian Research Council (ID: FT130100589). KA was supported by a Ronald Philip Griffiths Fellowship, The University of Melbourne. PK was supported by the Swiss National Science Foundation (SNSF) and the Swiss Society for Medicine and Biology Scholarships (ID: 148384). PM was supported by a NHMRC SPRF. MY was supported by a National Health and Medical Research Council of Australia Fellowship (ID: APP1021973).